What OS (Win XP/2000, etc) are you using? What type of anti-virus are you using and when was the last time you ran a scan? Have you performed any anti-spyware scans?
There are worms like W32/Lovgate-AD that, which in addition to other files, will drop iexplore.exe in C:\Windows\system32. The legit iexplore.exe is located in the C:\Program Files\Internet Explorer folder. The key is the location the file is running from.
You can download and use Process Explorer
to investigate all processes and gather additional information to identify and resolve problems. This tool will show the process CPU useage, a description and its path.
ishost.exe and ismini.exe are related to Trojan Zlob-SR and smitfraud infections. You probably did not remove all the files associated with this malware so I suggest you follow the generic instructions in How to remove the Smitfraud
If your running Win XP/2000, I also suggest that you download and scan with AVG Anti-Spyware 7.5
in "SAFE MODE
" if you can get there, otherwise scan in normal mode for now.(This is Ewdio 4.0 renamed. If you already have Ewido installed, please update to this version which has a special "clean driver" for removing persistent malware.)
Be sure to print out the AVG Anti-Spyware Install-Scan Instructions
and read the User Manual
Then perform these online Virus scans
:[Watch the Address bar in IE. You may receive alerts that "This site might require the following ActiveX control...Click here to install...". Click on that alert and then Click Install ActiveX component.]Trend Micro Housecall
<- Use "Autoclean" and manually delete what it can't clean
<- Accept default settings
. (does not remove adware/spyware but will autoclean for viruses & worms.