I will second SleepyDude's observation. Trying to block spam senders is like trying to hold back the ocean using the palm of your hand.
Spam filtering has become very, very sophisticated and very, very good at snagging only what it needs to snag with very rare exceptions. You are far better off when the occasional message makes it through a spam filter taking the time to do whatever your e-mail client or webmail requires to classify it as spam so that the filters get additional data to work with.
All I ever do with the Spam filter is to take an occasional quick look to see if something legitimate may have been accidentally trapped, and if so, moving it back to inbox and if not, emptying the Spam folder so there's only "fresh spam" when I next do the quick check.