, Welcome to bleeping computer...
You didn't provide much specifics,,, So I'll assume you are using XP or 2000. Were there any messages, what are the pop ups? What AV and spyware apps do you have? Which firewall are you using?
In SAFE MODE,install AVG Antispyware. This may take quite some time, an hour or so, depending on speed and infection How to start Windows in Safe Mode
First go here and print out the instructions
on install / scan with AVG
Be sure to check for the any updates to the program after you install these.
Download and run ( formerly known as ewido) AVG Antispyware 7.5
Following these instructions
Download and run Spybot Search & Destroy 1.4 (with out tea timer option)
Download and run SUPERAntispyware
, free version Home User
Now Run Windows OneCare Live
Be sure to click ONLY on the grey box below the picture of a wrench “Full Service Scan”
Again this may take some time especially it it needs to defragment the drive.
Please post back with any questions and results