I use Virtualbox 5.2.16 on my Windows 7 64-bit Professional host.
Recently, my already installed 64-bit windows VMs (from XP up to 8.1, haven't tested 10) have started BSODing when running for more than a few minutes. Reinstalling didn't help, as the installer BSOD'd during the "extracting files" phase. This doesn't seem to affect 32-bit guests, or 64-bit linux guests. Only 64-bit windows guests are affected it seems.
This is sometimes so bad that it brings my host down too. Sometimes with a BSOD relating do vboxdrv.sys, and sometimes just cut to black and then reboot (which I've never seen before in any other context).
I've made posts on the virtualbox forum about this, but they said it's likely a host issue. Not sure where to go from here. It's also deeply weird that it affects only 64-bit windows guests, specifically.