No, the last thing I'd consider moving is the Program Files, unless they're taking up the most space, which is very, very rare these days. You also can't really move these folders (not easily, anyway), but you can choose to install programs to folders on a drive other than C: when you install them.
I identified the user data folders of Photos, Music, and Videos because they are, by far, the most common space hogs. I don't move these folders, either, but empty them out with the secondary drive being the permanent archive and the existing folders on C: acting as staging areas that get used only for up/download and post processing (if any) immediately afterward. When that's complete the resulting items get moved to the permanent archive on the alternate drive.
Edited by britechguy, 03 April 2018 - 06:28 PM.
Brian AKA Bri the Tech Guy (website in my user profile) - Windows 10 Home, 64-Bit, Version 1803, Build 17134
Memory is a crazy woman that hoards rags and throws away food.
~ Austin O'Malley