I have some users at a remote shop site that connect to the main server via an appliance-based VPN (Juniper SRXs). It is not uncommon for it to take several minutes just for their email to open. Trying to save an attachment can also produce long delays. I've got them running in cached mode. I verified the Outlook data file is saved in the local appdata folder, not with their other "My Documents" files, which sync to the file server. These are physical computers, not virtuals, and they should have plenty of bandwidth. it's fiber 125/125 on the server side, and 325/25 through high speed cable internet on the remote side. Internet runs fine, and our internet Outlook web access seems to run fine, at least compared to other web-based email. I do think this is VPN related, because when i use outlook remotely from home, it doesn't use a VPN, but it accesses email through the web access. I have no issues there. These are also well spec'd machines used for running a CAD-like program all with discreet graphic cards and running windows 7 enterprise. Any ideas? i can provide more specific info if necessary.