Until UEFI computers became the norm, all I used was Universal USB Installer, then had to switch to Rufus to make the bootable USB stick work. However, that's been sometime back, the developers frequently update the app & is (likely) now up to par with the rest. While Rufus is also simple, one has to manually select which type of computer the ISO is for (UEFI/GPT or BIOS/MBR). Although when creating on the target computer, usually don't have to choose.
Will go back to UUI, my once longtime favorite, and see how it does at creating UEFI bootable images.
In regards to saving changes to the USB stick, known as Persistence, then a minimum of a 4GiB USB stick is required, and best to select that option when creating the bootable media. Assuming a 4GB stick is used, than go with a 2 GiB persistence file, while the option takes a couple more minutes to create, any changes between live sessions will be there when used the next time. Although it's best when possible to use a 8GiB USB stick (to create the fully allowed 4GiB persistence file), or a 8 GiB SDHC card attached to a USB card reader, have a 2GB model that's been used countless times for Linux installs & rescue media), it serves the same purpose as a regular USB stick. Many has these smaller SD/SDHC cards laying around after upgrading the one in a digital camera to 16-32 GiB & are still very useful, found the tip on the 'Make Use Of' site.
A quick word of caution, if you've not already done so, please create your Recovery Disc set (3 to 5 DVD's) before installing Linux Mint, as well as creating a Full disk image of the drive. While this may not seem important today, it is for several reasons. One being a fallback option & the other should you later desire to sell the computer. Models with the factory OS & created Recovery Disc set has more value (30 to 50%) than w/out it, plus the drive image will allow you to restore to the created point & reinstall the factory OS, using the needed hotkey at boot, varies by make/model. If by chance that hotkey is broken, then the Recovery Disc set will do the same, although slower, on the same size drive provided by the OEM or larger, usually won't work on smaller drives. This would give the buyer a freshly installed OS, just force shutdown after completion & (s)he will have the same out of the box experience as yourself when purchased.
Here's an excellent, free backup option in Macrium Reflect, just be sure to create the Recovery Media when installed (a download will be required for the needed files). Also, under the 'Other Tasks' tab, there's an option to add Macrium Reflect to the bootloader, saving a lot of time, yet please create the WinPE rescue media, if no CD/DVD burner is in place, the ISO can be stored to an external for later burning, or can use with Rufus to create a bootable ISO image.
Note that there's no 3rd party bundles with Macrium Reflect Free from File Hippo which I'm about to link, if chosen from the Macrium site, one will be redirected to Download.com, among the worse offenders of adding garbage along with what one wants. This is a safe link, have used hundreds of times w/out any issue. Registration shows, yet is optional, can select 'No' at time of install to reduce possible spam.
The WinPE ISO can also be used to clone, backup & restore drives when needed, huge difference between this and the Linux rescue media provided years back that allowed a restore only, which is still provided by huge OEM backup solutions like WD & Seagate. Macrium wins hands down.