No harm would be done taking out each and every one of them. Thats exactly what we do to 'em. They don't belong there. BUT, we don't want to delete legitimate system files, because of the consequences. That is why we look at the hjt logs so that both you and I know whats good & whats bad. And we use special software tools to do it for us, so we don't sit there and patiently delete so dang many of 'em.
Re-installation wipes the disk clean. You start over. So, if you have the Operating System CD's that Windows comes on, its really no problem. I've done it many times.
If you do not have the Operating System CD's then it's another matter. If that is the case, as it would be if the laptop was sold having the Windows (XP) or (ME) or (98) or (NT) I'd need to know the exact specs of your laptop to search out the procedure recommended by the manufacturer on "restoring the OS". Either way, the help I give would depend somewhat on answers from you. We can discuss it online, yes. It might take a couple days considering our time zones and the time it takes to get prepared and have all the info we need in place before we do it.
From the sounds of it, and what I learned from you last night in Chat, your laptop is suffering badly. It needs to be restored back to normal again.