For Google Chrome (all OS's), I've used both uBlockOrigin & Adblock Plus for years, although from time to time, have to disable uBlockOrigin on some sites, or won't be able to view content. When I have to do this, will weigh the importance of what I need (or want) to access versus my personal security.
Adblock Plus has been a staple with most all of my browsers since 2009, when first started using with Firefox 3.5 (release candidate), along with NoScript, arguably the best security extension on the market for any browser, there's been imitators of the extension, yet none like it by far. Later on, tried Ghostery, while a good tool for those who can manage the extension (many choices in there), I prefer to use global rules & enable access as needed. Then came uBlockOrigin 2-3 years back, recommended by a member on this site, tried & have stuck with it since.
When I want to do online banking, will boot into the latest version of Linux Mint & use the default Firefox as is, while not bulletproof, at least am behind a semi-hardware Firewall in my router called NAT (this is often overlooked by many), have never been compromised to date, although I understand that a disaster is a click away. So when I boot into a Live session for online banking, will use for that purpose only, and only by a burned, finalized DVD, which can't be written further into. A bootable USB stick defeats this security because can be written to. With the Live DVD, no disk access takes place, the session resides in memory only & becomes flushed upon shutdown or reboot.
So depending on what you're doing, booting from a Live DVD can be far more secure than a installed OS, w/out browser extensions. Also, it's important not to light up the browser like a holiday tree with extensions, too many causes one to be less responsive.
While there's no 'one size fits all' here, these are good tools to have, and am sure there's others, although as noted above, too many has an impact on performance, if I were to add another, would consider removing or at least disabling another until I see that the extension pans out.