I have a user with windows 10 O/S and office 365 installed. The issue is that office randomly becomes unresponsive and need to be closed and launched again to access the program(s). It started with Outlook and now has trickled into the other office programs. I have blown away his Outlook profile and created a new one. I have scanned his .ost and it did find errors but stated it fixed them. Not sure where to go from here.