To reinforce what zainmax has posted I have not found "significant differences" in the ISOs within a given release. There has been discussion on these forums about this before and they can and do change, but not congruent with the various build numbers within a version. Part of the Windows 10 install process always involves checking online for updates, so as long as you've got an ISO for the correct version it will update itself to the most recent build as part of applying updates during the install process.
There is, as has been previously noted, one "grand unified" ISO that will determine what edition (Home, Pro, Education, S) will be installed on your machine either based on the license key if this is a completely fresh installation or on what is recorded on Microsoft's servers for your hardware if you're reinstalling.
Brian AKA Bri the Tech Guy (website in my user profile) - Windows 10 Home, 64-Bit, Version 1803, Build 17134
Memory is a crazy woman that hoards rags and throws away food.
~ Austin O'Malley