I have seen this happen twice to two different users. They have laptops that they use to work remotely, which we have joined to our domain, but they log in with a local account. The laptops are Windows 10 version 1607 64-bit. What happens is that they are using their laptop, close the lid to put it away while at a meeting or something, open the laptop up and when they sign in their profile is blank. The profile date/time stamp is current, but the profile is completely blank. I can not find any traces of their previous profile contents, all programs are intact though.
The users report that there was no recovery mode or anything when turning the computer on and it booted as normal. Has anyone else come across this?