FAT32 and NTFS are the two types of formats which Windows uses. The FAT32 format has a max file size of 4GB, a NTFS format has a max file size of over 4TB, a huge difference. Microsoft has not used a FAT32 format in several generations of Windows. There are other benefits in using the NTFS format, but that's really not important for what you are doing.
I don't know what of my post you read, but the jist of it is the fact is that the file size and the folder size don't determine how large these can be. The size of the hdd (hard disk drive) or ssd (solid state drive) determines the size of these. When you hdd/sdd is full then you have reach the limit of the file size.
Looking at the Speccy I see that your C: drive only has 7% (19.6GB) of free space left, this is too full for adequate swap space. One of the uses of swap space in is for virtual memory. When you use applications that use a large amount of your resources, RAM, you could run out of adequate RAM. This is where the virtual memory comes into play, it takes up a small part of the load. You have 8GB of RAM, so unless you are using application for something like video editing you should never have a problem with RAM.
I would suggest transferring some of your data to one or both of your other drives. Both of the other drives have a lot of free space. A rule of thumb which had been reasonable was to maintain about 15% free space on the C: drive. I would be comfortable seeing 10% free space with your C: drive, that would give you 29.8GB of free space.
I hope this helps.