Well...first thing is that you have a motherboard and with that board comes a drivers disk. That will take care of any drivers that need to be installed and which Windows will not install automatically.
Between the installation of the new motherboard....very simple, using a screwdriver...and then installing Windows (with appropriate activation...and then running the drivers disk which comes with the motherboard...it's all simple.
First thing...read the motherboard installation manual/guide which comes with the board. It will lay out everything on the board in detail. It helps to find out where your control panel connectors, RAM slots, and PSU connectors should be, before you start trying to attach them.
I find making the front panel connections to be the hardest part of installing a motherboard and it's really not hard at all...it's one of those things that, once you've done it, you know.
Installing the CPU/fan/heatsink...can be irritating but just follow the instructions provided with the CPU.
Make sure RAM modules are firmly seated properly.
Make sure that the PSU switch at the rear...is in the ON position. Make sure that both PSU motherboard connections have been made properly.
One thing...remove your old hard drive from the system before you begin a new install...the old drive serves no purpose and could only be a possible item of confusion during any install of Windows.
Asus boards come with what I consider to be an excess amount of junk on their install disks. I suggest you ignore most of the flaky stuff and only go with the basic driver installs...you can install anything else from that disk once Windows is properly set up.
There are tons of guides covering new installs, new motherboards, etc...if you have any doubts, use Google to get a visual aid or a guide of some sort.
Just take your time...do a step at a time...you'll get it done .