What exactly do you wish to tweak?
Tweak in Windows 10 is usually aimed at applications that owners of computers with this operating system do not want running on their computers.
There are members who are concerned with applications that monitor Windows 10, specifically telemetry. This monitors security and reliability issues and is not suppose to peruse you private data. But there are those that are paranoid enough that they wish to disable this application.
Another application that some owners don't care for, for similar reason, it Cortana. It's a "personal assistant" which is suppose to enhance you Windows use. This was one of the first applications I disabled. But, this again is a personal choice.
Some people don't like the "revised" Start Menu. It does take a little getting to now it to be comfortable with it. But you can always use Clasic Shell which provides a Start Menu very similar to the Windows 7 menu.
One of the problems with each new version of Windows is the fact that there is always something new that may require a learning curve.
I would suggest leaving applications as they are and get to know them before making any decisions regarding tweaking anything.