I have had this problem for some time, and it's begun to happen so often to the point that I'm sick of trying to find my own solutions for it.
When I run games such as Grand Theft Auto 5 and Fallout 4, or intensive programs such as Adobe Premiere, I seem to run into an issue where my computer crashes after some time. The game/program will be running fine for a bit, then crash. The audio will then seem to glitch out, and each monitor changes to a random color (see http://imgur.com/a/Cey2g ).
My CPU had been getting high temperatures (around 80C) so I thought that was the problem. I purchased a CPU cooler so now the temperatures rest around 50C - 60C during intensive games, but I still get the crashes.
My GPU temperatures don't seem to be getting abnormally high. They looked like they were around 60C when I last was monitoring during GTAV.
I have tried removing one stick of RAM, and then swapping it out for the other, but that hasn't helped at all. I used the AMD Crimson (I believe that's the name) software to update my drivers, and I still get the issue.