I recently bought a new R9 380 (XFX 4G) and after about a month of gaming with no problems, I started getting somewhat infrequent crashes to desktop while playing games. These pretty quickly increased in frequency, and while playing a new game (Overwatch), I would occasionally get a full system crash with a blank red screen. I've ruled out heat as an issue - my CPU and GPU temperatures are both quite low while gaming (in the low 50s). I've tried running games with no other applications running and with most background processes culled (I heard MSI Afterburner and some Raptr stuff can cause crashes).I've also wiped and reinstalled the graphics drivers multiple times, both through the Windows tool and with DDU. I updated the mobo drivers (but not BIOS) after upgrading to Windows 10 a few months ago, and reinstalled the audio drivers (since Realtek HD Audio Manager started increasing the volume in one speaker but not the other - unsolved). I've tried running with one stick of RAM then the other on their own, and finally when none of this helped, I temporarily surrendered and switched back to my old GPU (GTX 750 Ti). With the old card I no longer get the crashes to desktop, but I occasionally get a system crash that displays the Windows compiling error information screen while a loud buzzing / humming noise plays through the headphones. If I instantly restart and opened any game back up, it crashes again in the same manner after only a few minutes. I'm guessing this indicates something other than the GPU is at fault, but I don't have the know-how to identify what's going wrong. My Mobo and CPU are both about two years old, while the power supply is a hand-me-down, so I'm not sure of its age, though it got little to no use before I put it in my system two years ago (it's several hundred watts larger than my system needs, and has ample 12v rails).
OS: Windows 10
GPU: Radeon R9 380 XFX 4G AND/OR NVIDIA GTX 750 Ti
CPU: Intel i5 4670K
Mobo: ASUS Maximus VI Hero
RAM: Crucial Ballistix Sport 8G (x2)
PSU: Rosewill 750W
Thanks in advance for any help you can provide! <3