I use a wireless mouse and keyboard and when I installed them much to my surprise they just worked ! However . . .
The best thing to do is to uninstall all your generic USB drivers, then shut down the computer and do a cold re-boot. This is somewhat simpler and less threatening than it sounds !
Click in turn 'Start - Control panel - System - Device manager (in the top left corner of the System screen)'. At the bottom of the small screen that will appear you will see an entry 'Universal Serial Bus controllers', expand this by clicking on the '+' sign at the side of this entry and you will see a list of USB controllers some of which will merely be called 'USB root hub'. Select each of these in turn, select 'Drivers' from the gray box that appears, and select 'Uninstall' and follow the prompts. This will uninstall the generic drivers.
Now shut down the system. Since you just uninstalled the mouse driver(s) you will have to use the keyboard - press the 'Windows' key, this will bring up the start panel, and use the tab key to move around the start panel until the shut down button is highlighted, then press 'Enter' and the computer will shut down. Next turn off the power supply - and remove the battery if it is a laptop - and hold the start button down for a few seconds. Then reconnect the power (and battery) and start up as normal. The USB drivers will automatically be re-installed as Windows starts. This should fix the problem. If it doesn't, post back.
If the computer is a laptop with a battery that is not easy or impossible to remove don't worry about removing it - just shut down and restart.
And remember for any future posts you make that information on your computer - make and model at a minimum - is very useful !