Tech support of Microsoft says concerning windows 10,that such a combination of windows defender 10,and Malwarebytes .org premium are not good for windows 10.
Only their recommendation of TREND MICRO is the best. They even sell this on their website. I told them they should not be selling any internet security package or endorsing any of them,but their own Windows Defender. They say this is the response to customer complaints about the performance of windows 10,and that Trend Micro is the best,and use no other than this.