Those files (and folders) are leftover items that are usually generated by Windows Updates and/or Windows Essentials. If I recall right, they're called GUID's or Global Unique Identifier items.
If I recall, a bug was fixed a couple of years ago where these items are (mostly if not all) deleted after WU/Windows Essentials are run. Since that time, I've only seen a few new items appear on my PC.
As a rule, it's ok to delete the files/folders but I'd run a HDD backup process (Clone or Image) before purging the items.
After I cloned my HDD, I purged those items from my PC a couple of years ago.
Most of them were located in my %LocalAppdata% folder, if I recall. A few were located in the top C:\ dir.
At that time, there were many items in my LocalAppdata folder so I used a VBscript to delete the items which sped up the process. It checks any of the "hex" folders to see if they're empty before removing the folders.
Attached is the script file in *.txt format. You can save it to your PC as any_name.vbs .
Edited by Scoop8, 29 September 2015 - 07:49 AM.