I guess it depends on what you consider "Enough" protection.
I believe in a layered approach.
Anti-malware programs all may find malware that others may not, and what you have selected is good, I would (and did) add much more.
Some I have running realtime like Windows Defender, Spybot (Teatimer), Ewido's new antispyware (free) ap, BHO Demon, Microsoft Malicious Spyware Removal Tool (Auto update) and Startup Monitor.
Others I run occasionally or when I am looking to make sure I have no problems existing.
Here are some I recommend.Freeware AntiSpyware and Security ProgramsSoftware firewalls with freeware versions
(Run only one and disable the ineffective Windows XP firewall)
ZoneAlarm (freeware) V. 6.1.744:http://www.download.com/ZoneAlarm/3000-10435_4-10039884.html
(you can have only one software firewall running. More than one will conflict)
Comodo firewall (freeware)http://www.personalfirewall.comodo.com/Antivirus programs - freeware
(you can only use one resident anti-virus program on your computer. More than one will conflict)
Avast Anti-virus freewarehttp://www.komando.com/bestshareware.aspAnti-malware freeware
(You can run as many of these as you wish. Generally there is no conflict between these and you should always run several since each may find malware that the others may not find)
Ad-Aware SE Personal - freeware http://www.lavasoft.com/http://fileforum.betanews.com/detail/Adawa...nal/965718306/1
Spybot S&D: http://www.safer-networking.org/en/index.html
Be sure to enable “Teatimer” which gives you realtime protection against malware invasion. (absolutely necessary)
Microsoft Windows Defender http://www.microsoft.com/athome/security/s...re/default.mspx
This also provides realtime protection. (absolutely necessary)
Ewido Antispyware Freehttp://free.grisoft.com/doc/20/lng/us/tpl/v5
Microsoft Malicious Software Removal Tool (Win XP and Win 2000):http://www.microsoft.com/security/malwareremove/default.mspx
A˛ - Free from http://www.majorgeeks.com/download4281.html
. Run it, click Search for Updates, then click Scan.
CW Shredder removes some variants of spyware known as the Coolwebsearch Trojan. The Trojan takes advantage of a flaw in a key component of Windows -- Microsoft's version of the Java Virtual Machine -- to install itself via popups often found on porn and illegal software (a.k.a. "warez") sites. Run CWShredder after installing, and have it look for updates. Then click the "Fix" button, and the program will both scan and fix any problems it finds. If your system does not have this kind of spyware, it will give you the good news.
Microsoft Baseline Security Analyzer (MBSA)
MBSA is an easy-to-use tool designed for the IT professional that helps small and medium businesses determine their security state in accordance with Microsoft security recommendations and offers specific remediation guidance. Improve your security management process by using MBSA to detect common security misconfigurations and missing security updates on your computer systems.http://www.microsoft.com/technet/security/...a2/default.mspxHijack This
and a variety of other tools for malware and pestwarehttp://184.108.40.206/~merijn/files/HijackThis.exe
Unless you are an expert in altering, editing or modifying the registry do not attempt to use “Hijack This” without expert assistance which you can get by following the instructions below:
How to submit a Hijack This loghttp://www.bleepingcomputer.com/forums/tutorial94.htmlhttp://www.bleepingcomputer.com/forums/How...s_Log-t956.htmlWeb based online Antivirus and anti-malware scans:
(these can be run regardless of whatever else you are using. You must use Internet Explorer to run these as they require ActiveX to function.)
Kaspersky Anti-Virus Web Scannerhttp://www.kaspersky.com/service?chapter=161739400#betatest
File scanner and virus scannerhttp://www.kaspersky.com/scanforvirus
Panda Activescan http://www.pandasoftware.com/activescan/co...n_principal.htmhttp://www.pandasoftware.com/products/activescan.htm
Trend Micro antivirus and malware scan:http://housecall-beta.trendmicro.com/en/st...orp.asp?id=scan
Etrust Anti-virus web scannerhttp://www3.ca.com/securityadvisor/virusinfo/scan.aspx
Avast Online scanhttp://onlinescan.avast.com/
F Secure online scanhttp://support.f-secure.com/ols/start.html
Ewido Online scanhttp://www.ewido.net/en/onlinescan/
More AV scans:http://security.symantec.com http://www.coledata.com/virusalert.htm http://www.cybertechhelp.com/html/misc/av.php http://www.pandasoftware.es/activescan/activescan-com.asp http://www.ravantivirus.com/scan/ http://www.bitdefender.com/
Trojan scans –
Windows Security Trojanscanhttp://windowsecurity.com/trojanscan
See instructions for it here:http://www.windowsecurity.com/trojanscan/trojanscan.asp
Parasite scan from Aumha:http://www.aumha.org/a/noads.php