Yesterday morning, my wife sat down at her desk and saw nothing but a bad image error window for an application. Computer had apparently rebooted overnight and in trying to x/close the window, wouldn't allow this, had to click on OK and that just presented a similar window for a different program - this happened over and over again, many times, apparently for every program that was trying to launch on startup. Searched and searched on another PC for what this might be - was finally able to run AVG which found something (I can't recall what) but indicated it couldn't be repaired/healed. Ended up trying multiple things throughout the day - ran Vipre according to those instructions in Safe Mode, ran SFS Scannow, Malwarebytes, AVG - all multiple times and in Safe Mode. Nothing (at least no threats related to fixing this problem) turned up. Found a post at this website/forum last night that referred to Combofix, but everything I see on this particular tool indicates that it isn't wise to use without expert assistance. This problem is like no other I've experienced, crippling. Help would be very much appreciated!
A bit more info - almost every single error indicated the program was "either not designed to run on Windows or it contains an error. Try installing the program again using the original installation media or contact your system administrator or the software vendor for support". I believe above this the window showed the program (program.exe) - Bad Image and the path C:\progra~1\movies~1 (example)\datamngr.dll. There was one instance noted that said: IAStorIcon.exe - Application Error Application has generated an exception that could not be handled. Process ID = 0X514 (1300), Thread ID = 0Xbf4 (3060) Click OK to terminate the application. Click CANCEL to debug the application.