You can configure quotas through File Server Resource manager (FSRM).
You can set up the location that contains users profile or home folders so that each user's own folder within that location automatically has its own quota created (however that quota has to be the same for all folders in that same location)
You can set hard quotas (that block further writing) and soft quotas (that only warn). Additionally you can configure it to hurl abuse via email at the errant user when they transgress.
More detail here - http://technet.microsoft.com/en-us/library/cc733029.aspx - It's a simple subject with big ramifications, so it's one those things to test, and test again (then when you're sure that you've got it right - test a bit more!)
I find that it is best used with group policy redirection of certain folders within users' profiles into their home folder (Documents, Downloads, Favourites etc.) See http://technet.microsoft.com/en-gb/library/cc732275.aspx. This in itself will likely cut profile sizes dramatically. Ensure that laptop users have caching of home folder contents turned on, so that their environment works when they are off the LAN. In this case we would apply the main quota to the home folders instead. (and maybe a secondary quota to the profile tree, that warned only)
If you have users who need different quotas, you could set up multiple home folder and multiple profile trees with different quotas on each.
Edited by x64, 10 January 2015 - 02:08 AM.