Suggest you uninstall Avast Internet Security and Comodo Firewall...then reinstall Avast Internet Security, update it and run a system scan.
I would uninstall File Hippo App Manager, described thus: "Upon installation and setup, it defines an auto-start registry entry which makes this program run on each Windows boot for all user logins. A scheduled task is added to Windows Task Scheduler in order to launch the program at various scheduled times (the schedule varies depending on the version). The software is designed to connect to the Internet and adds a Windows Firewall exception in order to do so without being interfered with."
So...I have to ask...what is the alleged benefit to a user...for installing this sort of thing?
TuneUp Utilities 2014 (HKLM-x32\...\TuneUp Utilities) (Version: 14.0.1000.340 - TuneUp Software)
TuneUp Utilities 2014 (x32 Version: 14.0.1000.340 - TuneUp Software) Hidden
TuneUp Utilities Language Pack (en-GB) (x32 Version: 13.0.4000.180 - TuneUp Software) Hidden\\
Uninstall, uninstall, uninstall...and don't even think of possibly resinstalling.
Microsoft support policy for the use of registry cleaning utilities - http://support.microsoft.com/kb/2563254
Registry cleaner - Wikipedia, the free encyclopedia - http://en.wikipedia.org/wiki/Registry_cleaner
Registry Cleaner FAQ, PC Support - http://pcsupport.about.com/od/registry-cleaner/a/registry-cleaner-faq.htm
Registry Cleaner, Animal - http://www.bleepingcomputer.com/forums/t/526247/tune-up-utilities-2014-problem/?p=3303494
Then...I would run the chkdsk /r command on the C: partition, followed by running the sfc /scannow command.
Chkdsk From Command Prompt, Win 7 - http://www.bleepingcomputer.com/forums/t/496613/contextmenu-is-causing-explorerexe-to-crash/?p=3067880
SFC -SCANNOW Run in Command Prompt at Boot - Windows 7 Forums - http://www.sevenforums.com/tutorials/139810-sfc-scannow-run-command-prompt-boot.html
Your C: partition is getting cramped...please move some of the large data files (videos, graphics, etc.) from C: to another partition. Minimum free space on C: should be circa 15%.