I was having this problem too. It started sometime in October. By the middle of November I had hundreds of thousands of folders (and millions of files) in AppData\Local\Temp with names like 17ec, 3b60, 49b4 and so on. Most of them had the following subfolders:
My computer was hopelessly slow and churning constantly, creating multiple new folders every minute or so. One day I spent a few hours deleting all of them, a screenful at a time. By the next day there were 24,000 new folders, containing over 150,000 files!
I ended up installing Bitdefender Internet Security 2015 about a week ago. The churning has stopped, and the pc is fast again. The package has a tool for deleting files from %Temp%, and it works instantly. I haven't checked it in the last few days, but I don't think the Temp folders are being created any more. So far I am very impressed with Bitdefender.