One Drive should have nothing to do with your problem.
You may have some type of hardware failure, or maybe it's the operating system that has gone whacky.
The fact that it's intermittent, makes it that much more confusing.
There are some things you could do to try to fix it, before considering going to your recovery features to reinstall the whole system, but they won't help if it's a hardware problem.
The first one will take 15 to 30 minutes.
Open a command window with Admin rights and copy and paste the following command, then hit enter.
After the SFC scannow job, the next thing is to schedule a diskcheck by pasting in the following,
chkdsk /r C:
then hit enter, then accept the scheduled diskcheck with "Y" for yes, then hit enter again.
The checkdisk will start at the next bootup.
All is well in Paradise.