I have a W7 Pro desktop unit connected to a windows domain. On this specific desktop, the cursor will lock (no mouse clicks works) although the directional mouse movement works. I have to hit Ctrl-alt-del , choose task manager and then when Task Manager shows, the mouse and keyboard will work. I do not see any error messages in the Windows Event Application and System logs. I ran the W7 Memory Diagnostic Tool and it found no errors. There is nothing highlighted in Device Manager. I see the same problem ( only not as often) in Safe Mode with Networking. There is a wireless mouse and keyboard and the batteries are new. Any ideas what to check?