Build 22.214.171.1240 is now available. One issue discovered during testing of the last beta was fixed.
I manually updated on top of 126.96.36.1999, without turning off Self Protection (SP), and a clean install was not necessary for me. A system restart was however mandatory.
After the restart, my first non-defragmented HDD Hyper Scan, with all options off, took 2:24 - a Threat scan, with everything checked, took 8:42. Yes - these times are relative but impressive and should still be representative.