Autoruns Help says that: If you are running Autoruns without administrative privileges on Windows Vista (and presumably later) and attempt to change the state of a global entry, you'll be denied access. Autoruns will display a dialog with a button that enables you to re-launch Autoruns with administrative rights.
That happens if I simply double-click on the Autoruns icon, but after Yes-ing thev UAC then Autoruns closes and there's another message"Error importing file: the system cannot find the path specified" which I OK, but then Autoruns re-opens with a blank window, and I have to refresh (F5) to restore the detailed view - then it works fine.
But if I simply right-click on the icon and select Run as Administrator - then no messages, no hold-ups, no hassle.
Perhaps you might suggest that in the introduction: