I don't know about exposing 4K sector sizes on an internal drive. Most drives I've seen recently don't have any jumpers on them at all. If the manufacturer does not provide a utility to enable it then it seems unlikely to be possible. BTW Toshiba drives may be re-branded Hitachi's, at least one I used recently still had a Hitachi sticker on it. I do know that certain external USB 3Tb and 4Tb drives have 4K sectors enabled, but I understand this is through emulation provided by the controller in the USB caddy.
Here is the fsutil for one of my external HDD's set up like that (a Samsung 3Tb USB drive):
My understanding is due to the 4K emulation provided by the USB controller, if it was removed from the caddy and connected by it's native SATA connection directly to the computer, it would be unreadable in it's current form.
Disadvantages of the 4K sectors sizes are that it's incompatible with some software - Windows 7 Backup for example and some other drive imaging software. Other than that it works OK. I've recently installed Paragon Backup & Recovery 2013 Free, which claims to have full support of both GUID partition tables and 4K sector drives. It does have drive imaging facilities, but not sure how it compares to Ghost in that respect. But like I said I've only recently put it on and am still getting to grips with it - it's fairly complex software.