I am at my wits end with this problem.
On and off, for the past several weeks, my HP desktop computer has been exhibiting a strange bug where no programs will open. Clicking a link on a taskbar, desktop, or Start menu shows the related program opening onto the taskbar briefly and fading out with no explanation. This computer has multiple accounts, and each account (except for mine) will run perfectly normally during this time. Additionally, attempts to fix it previously have utterly failed, and rebooting the computer had the possibility of a blue screen when Windows started up. In the past, this issue has appeared without cause and resolved itself after several hours of inactivity.
This time, though, it seems a little worse. Every other time I reboot my computer, I can guarantee a blue screen will appear on startup saying that crucial files have been affected. The next time I do, there is no blue screen, but my account will have the typical issue. If I run startup repair, I get a 10 minute wait before it says it simply cannot do anything to fix my computer and leaves it at that.
I can run the computer in safe mode, which is what I'm doing now. My first instinct was to run MalwareBytes and CCleaner, but neither found or identified anything worthwhile.
I am fairly confident that I can use the Registry, as I have done so successfully on a few occasions in the past, so if this is possibly registry based, I could manually do this.
If there is hope, please respond.
I would appreciate any and all help. Thanks.