I just got this problem on 2x Win7 and 2x Win8 machines today. (20 other machines are ok)
All happened within 1 hour of each other. multiple 30-60sec freezes with any and all programs (all office, trillian, notepad, firefox, ie, chrome, file explorer.... etc) in normal (not responsive showing up in titles). explorer.exe would crash multiple times as well.
Works perfectly fine in safe mode .
ran the following (in safe mode with networking)
rkill (found nothing)
malwarebyte rootkit scanner (nothing)
eset online (nothing)
I then ran Temp File Cleaner, but didnt help a bit.
Edited by mrgodai, 05 September 2013 - 03:18 PM.