I have tried Malwarebytes Anti-malware, SUPERAntiSpyware, Malwarebytes Rootkit, CCleaner, Avast, & Microsoft Security Essential scans. I've uninstalled unrecognized programs. I use Vista on HP Pavilion. I've tried to uninstall Internet Explorer however I'm prompted that I need permission! Help! I use Firefox with no problem. IE opens itself multiple times when I click screen. I've tried mouse properties as well. Any suggestions or comments welcome.