1) Advanced System Care's primary component is a registry cleaner. Registry cleaners CAUSE problems, they don't cure them. You should cease using Advanced System Care (and ALL registry cleaners) immediately.
2) Please define: "long time to start up". How long does it take to boot? How long does it take to boot to safe mode?
3) If a safe mode boot is fast, you can try to identify what process is causing the slow boot with a selective startup:
Open msconfig and on the General tab choose "selective startup" (uncheck all three items) and reboot. Does the problem still occur? If not, start adding items back to msconfig one or two at a time, rebooting after each change, until the problem reappears and you'll have identified the offending process. This is clearly a time consuming procedure, but it is the best way to determine if some process loading with the system is the cause of your problem.
After you've isolated the cause, do not use msconfig to permanently disable the process. Instead, if it is a service go to START - RUN and type: services.msc (then press enter) and disable the service OR, if it a program, you can download & run a simple app such as Mike Lin's Startup Control Panel (http://www.mlin.net/StartupCPL.shtml) to enable, disable, or otherwise manage startup programs.