There is no guarantee an anti-virus will detect or remove all variants of a threat, especially newer variants. That's why even the anti-virus vendors offer specialized tools. You would need to check with the vendor.
BTW, you just don't run some of these specialized tools just to see if they find anything...they don't work like typical scanning programs.
If you were infected with this type of malware you would be experiencing problems with your computer. These are some examples (all are not be present as signs depend on malware variant and extent of infection).
Signs of infection seen with Mebroot:
1. When attempting to log into ebay, Paypal, gmail, Yahoo! mail, user is redirected to a phishing screen asking for personal info (SS number, Credit card number, ATM pin). <- seen more with MBR infection
2. Random Audio/Radio/Voice ads & sounds such as "Congratulations You've Won" audio.
3. Commercials in foreign languages.
4. Pop ups when no browser is open.
5. Mouse clicking sounds.
6. BSOD and Stop 0x0000007B error message while booting the system.
Signs of infection seen with TDSS:
1. Google search results redirected as the malware modifies DNS query results.
2. Infected (patched) files like atapi.sys, iastor.sys and others in the Windows drivers folder.
3. Internet Explorer opens on its own.
4. BSODs, slown computer and poor performance.
5. Random Audio/Radio/Voice ads.
5. Repeated Fake alerts indicating the computer is infected.
7. Frequent IExplore.exe instances.
8. Symantec Anti-virus reports: [SID: 23615] HTTPS Tidserv Request detected, HTTP Tidserv Request detected.
Signs of infection seen with TDL4, TDL4/MaxSS bootkit:
1. Redirections in all browsers.
2. Infected consrv.dll file which places various files in a random folder in the systemroot\INSTALLER folder.
3. Hidden malicious partition <- cannot be modified through Disk Management within Windows.
4. Presence of C:\WINDOWS\$NtUninstallKB3057$, %WinDir%\$NtUninstallKB32069$, etc folder
5. Booting issues.
6. Affects both x64 and x32 Windows
7. Infected/modified Master Boot Record (MBR)
8. Infected/modified Partition Table
9. Infected/modified VBR (volume boot record)
If you're experiencing any of these problems you can get expert help in our Virus, Trojan, Spyware, and Malware Removal Logs forum