The only things I can suggest are very basic.
Go to Control Panel. Administrative Tools/Computer Management/Device Manager. Expand Sound, video and game controllers. Highlight your sound card, right click, choose Uninstall. After the uninstall reboot your computer. Reinstall the drivers from the disk that came with the card or from the manufacturers website. If you use the website I suggest you find the drivers BEFORE you uninstall. Save the driver file to your desktop.
If that doesn't work:
Open the case and make sure the card is firmly seated in the slot.
Make sure the speakers are plugged into the sound card instead of on board sound.
Open up a music file and play it. Remove the speaker from the port and try it in the other spots to see if by some chance it is in the wrong place.
Go to Control Panel. Look for something associated with your sound card. If you see it open it and look to see if you can change any settings. This should be done while a music file or youtube video is playing.
What operating system are you using?
Edited by Queen-Evie, 29 January 2013 - 10:19 AM.