This is what we have in place for our domain.
Windows Server Backup (Included with windows)
1. I'll back up files and folders or a system state depending on what I'm trying to back up, and have it save (and overwrite daily) to a folder my file server.
2. After that, I use Symantec BackupExec on our backup server to backup the directory on the file server to the SAN (which is physically linked to the backup server via FIOS)
We have scheduled jobs set up for both programs, so its completely hands off. Very easy to set up, too.
Edited by akoch, 25 January 2012 - 04:26 PM.