We are losing our minds, we have about twenty machines internally in our environment that are repeatedly trying to go out and contact that IP above, we have isolated them and blocked access on the firewall... and are just about to reimage the machines and be done with it. But as a last chance I am checking here (I am not sure if you support business type machines and if you don't and know somewhere that does please let me know). This is what has been run... Malwarebytes, SuperAntispyware, TDSSKiller, Microsoft Malicious Removal Tool, MS ForeFront and as last resort ComboFix none of them are finding anything.
if this is something that isn't allowed here, sorry for the intrusion. I am long time lurker and I use this as my primary site for cleaning up Spyware/Malware at work.