Posted 08 March 2011 - 12:20 PM
RKill is only useful when there is active malware running (for example a rogue application) and tools like Malwarebytes Antimalware cannot be started. However, it can never hurt to run it, since it only stops processes. If there are no malicious processes to terminate, it simply will not do anything.
I never recommend using System Restore to get rid of an infection, because often malware will infect restore points as well. This can lead to malware being restored as well, or, if malware has corrupted the used system restore point, it can result in a computer that will not function properly (or even not start Windows at all).
When you choose to do a system restore in such a situation, it is indeed a good idea to run a scan with for example MBAM afterwards.
"Now faith is the substance of things hoped for, the evidence of things not seen."
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Malware analyst @ Emsisoft