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You need to delete them from the Administrator's account. For now disable the accounts from the dministrator 's account. If you have a malious program controlling them blocking them may work bette than deleting hem for now. Also set thier accounts type to limited, and restrict them.
Have you run antivirus and antispyware? Do you have a firewall installed.
I have Norton Corporate antivirus , with a McAfee firewall. I use a couple of antispy programs. I run them all during the night.
The PC is mine but I access my company network form home. I think they have downloaded software that allows the company to update certain programs that I use. The software is call Marimba. I will check of these two users belong to my employer.