Turning off UAC is never a good idea, even with the usual security measures in place.
The short time I used Vista, UAC was a nuisance, and improved greatly in 7.
I agree with bruce, UAC has saved me several times.
If you use certain programs regularly, you may want to look at this article: http://maximumpcguides.com/windows-vista/r...ut-uac-prompts/
The catch is it will only work if you start the program from a link (.lnk). This isn't a problem with most people, but you can't run the file that needs access directly.
I use notepad++ for most of my editing. I give it elevated permissions because I edit system files with it, and it makes my life easier. If I try to open a .txt, I will be prompted for admin rights because the file calls the .exe directly, not the .lnk you would create in the above link.