Combofix won't run unless in safe mode

I have a system that will not run combofix unless it is in safe mode. i have ran superantispyware and malwarebytes which cleaned out several infections. once that was done, hijack this was able to run. i tried running combofix and it would start to load, then stop. i started in safe mode, and it ran. said it detected presence of a rootkit and asked to reboot. i rebooted, combofix loaded, but did not run. i rebooted again in safe mode, ran combofix again, and it completed, but bailed on creating the log file. i am currently running it again in safe mode, under the user account and it is preparing log report. if it does not finish, any suggestions?
thanks in advance.

Edited by Orange Blossom, 01 July 2010 - 08:28 PM.
Move to AII as no logs posted and prep. guide not followed. ~ OB

Note the blue text above this forum.. Please go here....
Preparation Guide ,do steps 6 - 9.

Create a DDS log and post it in the new topic explained in step 9,which is here Virus, Trojan, Spyware, and Malware Removal Logs and not in this topic,thanks.
If Gmer won't run,skip it and move on.
Let me know if that went well.

finally got it to run and it was successful. looks like everything is back to normal.
thanx

You're welcome.
Now you should Create a New Restore Point to prevent possible reinfection from an old one. Some of the malware you picked up could have been backed up, renamed and saved in System Restore. Since this is a protected directory your tools cannot access to delete these files, they sometimes can reinfect your system if you accidentally use an old restore point. Setting a new restore point AFTER cleaning your system will help prevent this and enable your computer to "roll-back" to a clean working state.

The easiest and safest way to do this is:

• Go to Start > Programs > Accessories > System Tools and click "System Restore".
• Choose the radio button marked "Create a Restore Point" on the first screen then click "Next". Give the R.P. a name, then click "Create". The new point will be stamped with the current date and time. Keep a log of this so you can find it easily should you need to use System Restore.

• Then use Disk Cleanup to remove all but the most recently created Restore Point.
• Go to Start > Run and type: Cleanmgr
• Click "Ok". Disk Cleanup will scan your files for several minutes, then open.
• Click the "More Options" tab, then click the "Clean up" button under System Restore.
• Click Ok. You will be prompted with "Are you sure you want to delete all but the most recent restore point?"
• Click Yes, then click Ok.
• Click Yes again when prompted with "Are you sure you want to perform these actions?"
• Disk Cleanup will remove the files and close automatically.

Vista and Windows 7 users can refer to these links: Create a New Restore Point in Vista or Windows 7 and Disk Cleanup in Vista.