As the note at the top of this forum says, you should not be using ComboFix without the help of someone who is trained in its use. It's a powerful program that can be potentially damaging to your system; it is not like other virus/malware software. If you want more details see this
What type of file are you trying to open? This is only occurring on certain files or anything on your second hard drive?
If you're really concerned about a virus (what you describe may or may not be virus related based on the info given) I would suggest following this
guide and posting the resulting logs as instructed.