An excellent FREE tool to back up your registry is ERUNT: http://www.larshederer.homepage.t-online.de/erunt/
Also read: "How to Backup The System Registry": http://vil.nai.com/vil/SystemHelpDocs/RegBack.htm
WildTangent is a video game software company specializing in online games. Its gaming plugin contains the WildTangent Web Driver, WildTangent Multiplayer Library, WildTangent Updater and WildTangent GameChannel. The WildTangent Web Driver is their technology that allows you to play 3D games over the Internet. Although its not technically considered spyware it does have built in components to update itself and gather information about the computer system.
MyWebSearch is an Internet Explorer toolbar part of the Fun Web Products suite of utilities such as Smiley Central, Cursor Mania, My Mail Stationary, My Mail Signature, PopSwatter, Popular Screensavers, and the My Way website portal. MyWebSearch is not technically malware but it is thought to be bad by many experts since the program can introduce malware along with it.
They both create registry entries that the HJT Team will be able to identify and help you remove properly. acklan has provided good advice by instructing you to post a log in the HJT forum.