The easiest way to boot into safe mode is to restart your computer, and then while the computer booting, start tapping F8 until you see a black screen with whit text. You should see then see different boot options and I would chose the "Safe Mode Without Networking" option. Then log into windows like normal and then try running SUPERAntispyware
Both of those actually have different things you can try, such as rkill, which should help get through a full scan. Also, if you decide to try SUPERAntispyware, make sure you install it normal mode first (if possible) in order to get the most updated definitions. Then boot into safe mode to do a complete scan with SAS.
For more info on how to boot into safe mode, try this link http://www.bleepingcomputer.com/tutorials/how-to-start-windows-in-safe-mode/
If you can get through some of those scans, please post the logs for me to take a look at it.
Let me know if you have any questions.
Edited by certifiedgeek, 25 April 2010 - 01:54 PM.