You can certainly run malware scans from your system on any drive connected via USB.
I would suggest running scans with Malwarebytes...your installed AV program...and SUPERAntiSpyware.
You can also try to run the chkdsk /r command from your system while the drive is attached. To do so, see the following:
Graphical Chkdsk Interface - http://searchenterprisedesktop.techtarget....1276030,00.html
. Ignore the ads, the procedure for running chkdsk is the same in Vista and XP. Important: Put checks in both options presented (Automatically fix, Scan for).7B STOP error
info at http://www.aumha.org/a/stop.htm
, scroll down to 7B left column. Often these can be hard drive or file system problems. The chkdsk /r command is able to overcome some such errors, but not all.