If you're using the new Avast5, which I use, it now has anti-spyware built in! I also use Malwarebytes Antimalware as an on-demand scanner only. There have been reported problems running the new Avast5 with MBAM running realtime. I've always used Comodo FW with Defense+ enabled. It, along with Avast5 AV, are running just fine on my Win7 x64 Home Premium on a brand new pc.
Edited by buttoni, 03 February 2010 - 10:30 PM.
HP Pavilion desktop p6270z; 8 GB ram; Win7 Home Premium x64 bit; FX 4.0; DSL 2Wire modem/router; MVPS Hosts; Comodo FW 5.3(D+ & Sandbox enabled); MSSE; MBAM on demand.