DOS isn't much fazed what kind of computer it wakes up & finds itself on. I've run various flavours of MS-DOS, PC-DOS, DR-DOS, FreeDOS, OpenDOS etc on systems from 9.45 MHz 8088 up to 2.8GHz P4.
You'll need to allow for some limitations, depending on version - the older the version the more significant those become.
MS-DOS 7.10 and equivalents give the greatest capabilities, including access to more than 64GB of memory and FAT32/Long Filename capability.
Older versions most significant limit is the restriction to the FAT16 file system, so partitions are limited to 2GB maximum size, and filenames are 8.3 format. As far as MS-DOS goes, 6.2x was the best developed pre-7 OS, DOS5 was less refined but was the breakthrough in escaping the 640K barrier to make the most of 386+ CPUs.
MS-DOS 3.3 was the best developed pre-5 version, and makes the most of sub-386 systems.
Vernon Frazee's listing of the MS-DOS Commands is useful:http://www.vfrazee.com/ms-dos/6.22/help/
and for a general listing/comparison of DOS versions:http://en.wikipedia.org/wiki/Comparison_of...erating_systems