It does? Are you counting images, cookies, popups? S&D is very old school tool and numbers does not necessarily equal quality. A do-it-all-but-not-really-great-at-anything tool I think. Dumping S&D immunizing is not a major loss of anything but weekly somewhat updated blacklists which can be found elsewhere in few seconds
Try Adblock Plus and Easylist subscription for a start. Not really important unless Firefox files gets messed up and sabaithaime actually use Firefox ;) IE8 no longer has issue with long blocking lists in registry but still not settled if Firefox problem is relevant last I looked it up. Try install Sqlite manager, check integrity of sqlite files. If corrupted there is a problem. Very annoying since hard to fix unless database expert.