I posted all of the information and combofix log file Here .
Any help greatly appreciated.
There were only 2 user accounts on this system, Admin & Guest(<- which I could not delete for some reason) I rebooted the machine, and now the mouse no longer works , and the 2 user accounts are labeled as Admin (same old) and the second is labeled as ADMINISTRATOR. I immediately disconnected the system from the network, but thats where it stands now .
Any help would be greatly appreciated.